September 23, 2010

BioCision Launches CryoPrep System for Efficient and Highly Reproducible Cell Preservation

MILL VALLEY, Calif. --(BUSINESS WIRE)-- BioCision LLC, the CoolPrep™ company, announced today that it has expanded its line of innovative benchtop sample handling tools with the launch of the CryoPrep System™, a modular complete solution for cell freezing procedures. The CryoPrep System provides ice-free cryo vial cooling, one-handed vial opening and closing, convenient portability of cell samples, and a controlled rate of cell freezing without the use of alcohol.

Comprised of three precision-designed and -manufactured products – CoolBox™, CoolRack™ CFT and CoolCell™ – the CryoPrep System brings an additional element of versatility to BioCision’s product line, by giving researchers a kit that can be used for a variety of cell freezing procedures. The compact design and ice-free cartridge technology of the CoolRack and CoolBox combination, for example, make them ideal for ice-free vial cooling in tissue culture hoods; yet dry ice, wet ice or liquid nitrogen may also be used as cooling sources.

“The CryoPrep System is an ideal workstation set for ice-free cold cryo vial preparation and alcohol-free cell freezing, enhancing both efficiency and reproducibility,” said Dr. Tiina Sepp, vice president of new product development at BioCision. “Up to 30 cryo vial samples can be kept cold and dry, and opened or closed with one hand using the CoolRack CFT in the CoolBox. Once vials are prepared, the CoolCell provides alcohol-free -1oC/minute cell freezing in a –80℃ freezer or dry ice locker. The elimination of alcohol means extremely high reproducibility and no maintenance.”

The innovative CoolBox 30 System accommodates all 30-well CoolRacks and comes with a 2℃ cartridge for ice-free cell sample cooling. The cartridges consist of a gel pack with a thermo-conductive alloy shell, which enables fast cooling and recharge in a standard –20℃ lab freezer, and provides continuous uniform temperature to all samples, eliminating “edge effect.”

The 30-well CoolRack CFT features a unique well design that holds any 12.5mm cryo vial securely, for convenient one-handed opening and closing. CoolRack’s high thermo-conductivity ensures rapid and reproducible equilibration of all wells to within 0.1℃ of the source temperature. In addition to eliminating temperature variability and providing stable, compact organization, CoolRack saves time and reduces user errors and accidents commonly associated with directly immersing tubes in dry ice, dry ice/alcohol slurries or liquid nitrogen.

CoolCell holds 12 screw cap 1ml or 2ml cryo tubes and features a solid thermal core for consistent, controlled –1℃/minute cell freezing in a –80℃ freezer, without any alcohol. Requiring only minutes between freezing cycles and no maintenance, CoolCell is ideal for multiple batch freezing, ensuring identical freezing for all samples. The result is increased reproducibility and superior cell viability and function for scientific, clinical and diagnostic procedures.

Because of the low thermal mass design, CoolCell releases only one-third the heat given off by an alcohol-filled container. This means multiple CoolCells may be frozen simultaneously in a –80℃ freezer without warming up the freezer or jeopardizing previously frozen samples.

About BioCision

BioCision LLC, the CoolPrep™ company, designs, manufactures and markets modular benchtop tools for biomedical samples. BioCision's patent-pending sample preparation products enable researchers to achieve high reproducibility and consistency – experiment to experiment, lab to lab and clinical site to clinical site. CoolProducts™ are widely used by researchers in the pharmaceutical, biotechnology, academic and health care industries worldwide to ensure organized, error-free and standardized sample handling. BioCision was founded in 2007 by a group of scientists, biomedical engineers and drug development experts. For more information, visit



Susan Thomas, for BioCision,
(510) 381-5181 or
Rolf Ehrhardt, CEO, (888) 478-2221

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CoolCell® Controlled-rate cell freezing equivalent to CRFs

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BioCision is a life science research and development company that develops products and solutions for process standardization throughout the healthcare industry through the application of advanced thermal regulation principles and technologies. The intuitive design and interconnectivity of BioCision products enables researchers, clinicians and manufacturers to protect the integrity of temperature-sensitive therapeutics, biological samples, and biomaterials. By comprehensively addressing temperature stability, BioCision strives to improve the success of therapeutic discovery and development and enable effective care delivery.

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