September 22, 2010

BioCision Releases CoolBox for Ice-Free Cooling and Freezing of Biomedical Samples

Novel Reusable Cartridges Allow Portability and All-Day Ice-Free Temperature Control

MILL VALLEY, Calif. -- BioCision LLC, the CoolPrep™ company, announced today that it has released CoolBox, an innovative cooling and freezing system for all-day ice-free temperature control of biomedical samples. The CoolBox systems come with a reusable cartridge that for the first time gives researchers a portable, convenient method for achieving unlimited cooling duration without the temperature variability and contamination risks associated with ice- or gel-based products.

Unlike sealed plastic coolers, which require refreezing overnight, CoolBox provides unlimited cooling duration by simply switching cartridges. The cartridges consist of a gel pack with a novel thermo-conductive alloy shell, which enables fast recharge in a standard -20℃ lab freezer. A single cartridge provides 4 to 10 hours of ice-free cooling at 0.5℃ to 4℃, depending on whether the CoolBox lid is off or on. When a CoolRack is placed on the cartridge, the system provides unparalleled ice-free temperature consistency, eliminating “edge-effect” commonly found with plastic cooling boxes.

The compact design and ice-free technology make CoolBox ideal for use in tissue culture hoods, biosafety cabinets, GMP suites and in other situations where space is restricted or where ice could be a source of contamination. The light-weight, fracture-proof construction also makes CoolBox highly portable, facilitating its use for any biomedical sample collection and ensuring the protection of samples during transportation between laboratories.

“The CoolBox system can be used with either of the ice-free cooling cartridges or with ice, dry ice or liquid nitrogen as cooling sources. Regardless of the coolant, all wells will be continuously within 0.1℃ of the cooling source. And with five temperature ranges and a variety of thermo-conductive CoolRack tube or plate modules which can be inserted, CoolBox is a uniquely versatile option for benchtop cooling or freezing,” said Brian Schryver, Vice President, Research and Product Development at BioCision.

The CoolBox system accommodates a variety of thermo-conductive CoolRack and CoolSink modules for microfuge tubes, cryo vials, FACS tubes, mass spec vials, SBS-format multi-well plates and PCR plates, tubes and strips. BioCision's CoolBox PCR96 and CoolBox PCR384, for example, make PCR set up ice-free and hassle-free. Each system kit includes one CoolBox, one CoolRack PCR (either 384- or 96-well) and one +2℃ cooling cartridge. Additional +2℃ cartridges are available separately. Experimental reproducibility is enhanced by true iso-temperature control during the entire cooling period and the excellent thermo-conductivity of CoolRack PCR ensures the system will quickly equilibrate to +2℃ with less than 0.1℃ variation between wells, eliminating temperature inconsistencies between center and outer rows.

In addition to CoolRack PCR384 and CoolRack PCR96, the CoolBox Microplate System is also compatible with all CoolSink plate modules that accomodate SBS format multi-well plates and CoolRacks that hold SBS format tube arrays such as CoolRack 1mlx96 for 1ml storage tubes such as from Matrix, Micronics and others.

The CoolBox 30 System accommodates all 30-well CoolRack tube modules and comes with one 2℃ cartridge, an insulator pad and a red stage to be used with ice or dry ice.

About BioCision

BioCision LLC, the CoolPrep™ company, designs, manufactures and markets modular benchtop tools for biomedical samples. BioCision's patent-pending sample preparation products enable researchers to achieve high reproducibility and consistency – experiment to experiment, lab to lab and clinical site to clinical site. CoolProducts™ are widely used by researchers in the pharmaceutical, biotechnology, academic and health care industries worldwide to ensure organized, error-free and standardized sample handling. BioCision was founded in 2007 by a group of scientists, biomedical engineers and drug development experts. For more information, visit



Susan Thomas, for BioCision,
(510) 381-5181 or
Rolf Ehrhardt, CEO, (888) 478-2221

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BioCision is a life science research and development company that develops products and solutions for process standardization throughout the healthcare industry through the application of advanced thermal regulation principles and technologies. The intuitive design and interconnectivity of BioCision products enables researchers, clinicians and manufacturers to protect the integrity of temperature-sensitive therapeutics, biological samples, and biomaterials. By comprehensively addressing temperature stability, BioCision strives to improve the success of therapeutic discovery and development and enable effective care delivery.

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